Necrotizing myopathies
نویسندگان
چکیده
منابع مشابه
Acquired necrotizing myopathies opyright
Purpose of review Necrotizing myopathy exhibits a specific histological pattern, characterized by significant necrosis, with simultaneous muscle fiber regeneration, but without or with little inflammation. This histological pattern may be observed in acquired myopathies but also in muscular dystrophy. Acquired necrotizing myopathy can be secondary to drugs or toxics agents, and if not, autoimmu...
متن کاملInflammatory or necrotizing myopathies, myositides and other acquired myopathies, new insight in 2011.
As reminded by D. Hilton-Jones in this issue’s review [1], the classification of myositides is currently changing. Since 1975, when Peter and Bohan [2] defined the diagnostic criteria for polymyositis (PM) and dermatomyositis (DM), the development of new pathological tools [3,4] permitted to refine the diagnosis criteria, but also, together with fundamental research in immunology [5] and neuros...
متن کاملAnti-HMGCR Autoantibodies in European Patients With Autoimmune Necrotizing Myopathies
Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers identified autoantibodies (aAb) against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients with NAM, especially in statin-exposed patients. Here we report what is to our knowledge the first European coh...
متن کاملNecrotizing Autoimmune Myopathy: A Rare Variant of Idiopathic Inflammatory Myopathies
Idiopathic inflammatory myopathies are an unusual group of myopathies with annual incidence of 1 in 100 000 people in the United States. Necrotizing autoimmune myopathy comprises only 16% of this group. It usually presents with severe proximal weakness, lower extremity weakness, and severe fatigue while very rarely does it present with dysphagia and respiratory muscle weakness. Statin use, canc...
متن کاملHigh risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody.
Cancer can occur in patients with inflammatory myopathies. This association is mainly observed in dermatomyositis, and myositis-specific antibodies have allowed us to delineate patients at an increased risk. Malignancy is also reported in patients with necrotizing autoimmune myopathies, but the risk remains elusive. Anti-signal recognition particle or anti-HMGCR antibodies have been specificall...
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ژورنال
عنوان ژورنال: Current Opinion in Rheumatology
سال: 2014
ISSN: 1040-8711
DOI: 10.1097/bor.0000000000000106